BDBM50358804 CHEMBL1922933

SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=NMYGSMGORGHTCL-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50358804   

TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50358804(CHEMBL1922933)
Affinity DataIC50: 10nMAssay Description:Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetGlucagon receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50358804(CHEMBL1922933)
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetGastric inhibitory polypeptide receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50358804(CHEMBL1922933)
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity at human GIP receptor assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50358804(CHEMBL1922933)
Affinity DataIC50: 3.70E+3nMAssay Description:Displacement of [35S]-MK-499 from human ERG expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetGlucagon-like peptide 1 receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50358804(CHEMBL1922933)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human GLP1 receptor assessed as inhibition of cAMP productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50358804(CHEMBL1922933)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50358804(CHEMBL1922933)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50358804(CHEMBL1922933)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed