BDBM50359376 CHEMBL1929400::CHEMBL1929401

SMILES Nc1nc2ccccc2nc1NC(=O)c1ccc(CN2CCCCC2)cc1

InChI Key InChIKey=SXTDBNDGQWAIKW-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50359376   

TargetHistamine H3 receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50359376(CHEMBL1929400 | CHEMBL1929401)
Affinity DataIC50: 171nMAssay Description:Inverse agonist activity at histamine H3 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/his...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50359376(CHEMBL1929400 | CHEMBL1929401)
Affinity DataIC50: 189nMAssay Description:Inverse agonist activity at histamine H3 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/his...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50359376(CHEMBL1929400 | CHEMBL1929401)
Affinity DataIC50: 280nMAssay Description:Antagonist activity at histamine H3 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50359376(CHEMBL1929400 | CHEMBL1929401)
Affinity DataIC50: 313nMAssay Description:Inhibition of AChE in rat cortex homogenates using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50359376(CHEMBL1929400 | CHEMBL1929401)
Affinity DataIC50: 483nMAssay Description:Inhibition of AChE in rat cortex homogenates using acetylthiocholine iodide as substrate after 15 mins by Ellman's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50359376(CHEMBL1929400 | CHEMBL1929401)
Affinity DataIC50: 511nMAssay Description:Antagonist activity at histamine H3 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50359376(CHEMBL1929400 | CHEMBL1929401)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetHistamine H4 receptor(Human)
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50359376(CHEMBL1929400 | CHEMBL1929401)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at histamine H4 receptor expressed in HEK293 cells co-transfected with pCRE-Luc gene assessed as inhibition of forskolin/histamin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed