BDBM50364653 CHEMBL1951443

SMILES CC(C)NC(=O)c1cccc(NC(=O)Nc2ccc(cc2)-c2ccncc2)c1

InChI Key InChIKey=WJTBCUZNVGPRTM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50364653   

TargetRho-associated protein kinase 2(Human)
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50364653(CHEMBL1951443)
Affinity DataIC50: 90nMAssay Description:Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK peptide substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50364653(CHEMBL1951443)
Affinity DataIC50: 130nMAssay Description:Inhibition of recombinant human CYP3A4 in supersomes using midazolam as substrate after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A5(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50364653(CHEMBL1951443)
Affinity DataIC50: 980nMAssay Description:Inhibition of recombinant human CYP3A5 in supersomes using midazolam as substrate after 5 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Translational Research Institute

Curated by ChEMBL
LigandPNGBDBM50364653(CHEMBL1951443)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Limk1 using cofilin substrate, ATP and [gamma33P]ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2016
Entry Details Article
PubMed