BDBM50365480 CHEMBL1957366

SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1ccccc1OC(F)(F)F

InChI Key InChIKey=VHBHGRJDLFMVBX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50365480   

LigandPNGBDBM50365480(CHEMBL1957366)
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50365480(CHEMBL1957366)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50365480(CHEMBL1957366)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant full length PDE2A3 using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
LigandPNGBDBM50365480(CHEMBL1957366)
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human recombinant PDE4B catalytic domain using cAMP as substrate preincubated for 20 mins measured after 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed