BDBM50366081 CHEMBL1956898

SMILES COc1cc(Cn2ccc3c(Nc4cccc(Br)c4)nc(N)nc23)cc(OC)c1OC

InChI Key InChIKey=MXJWLONICANFEW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50366081   

TargetPlatelet-derived growth factor receptor beta(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50366081(CHEMBL1956898)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of PDGFBB-induced PDGFRbeta autophosphorylation in human SF539 cells incubated for 60 mins prior to PDGFBB-induction measured after 10 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50366081(CHEMBL1956898)
Affinity DataIC50: 2.57E+4nMAssay Description:Inhibition of VEGF-induced VEGFR2 autophosphorylation in human U251 cells incubated for 60 mins prior to VEGF-induction measured after 10 mins by pho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50366081(CHEMBL1956898)
Affinity DataIC50: 1.57E+5nMAssay Description:Inhibition of VEGF-induced VEGFR1 autophosphorylation in human A498 cells incubated for 60 mins prior to VEGF-induction measured after 10 mins by pho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50366081(CHEMBL1956898)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of EGF-induced EGFR autophosphorylation in human A431 cells incubated for 60 mins prior to EGF-induction measured after 10 mins by phospho...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed