BDBM50370625 CHEMBL4173095::US10954217, Example 00241

SMILES CC(=C)CN1CCN(CC1)c1ccc2CCN(Cc2c1)C(=O)OCc1ccccc1

InChI Key InChIKey=BOIPWYRNMCLWCD-UHFFFAOYSA-N

Data  13 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50370625   

TargetSigma intracellular receptor 2(Rat)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-ditolylguanidine from sigma2 receptor in rat PC12 cells by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
University Of Texas

US Patent
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi:  25nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi:  245nMAssay Description:Displacement of [3H]-Pentazocine from sigma1 receptor in guinea pig brain membrane by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
University Of Texas

US Patent
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi:  245nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent

TargetD(3) dopamine receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi:  264nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D3 expressed in HEKT cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi:  869nMAssay Description:Displacement of [3H]-Pyrilamine from human histamine H1 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting meth...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi:  876nMAssay Description:Displacement of [3H]-Rauwolscine from human adrenergic alpha2A receptor expressed in stable MDCK cells after 90 mins by microbeta scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi:  985nMAssay Description:Displacement of [125I]-iodoaminopotentidine from human histamine H2 receptor expressed in stable HEK cells after 90 mins by microbeta scintillation c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1E(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi:  1.24E+3nMAssay Description:Displacement of [3H]-5-HT from human 5-HT1E receptor expressed in stable HEK cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi:  1.34E+3nMAssay Description:Displacement of [3H]-Mesulergine from human 5-HT2C receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-2B adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi:  2.44E+3nMAssay Description:Displacement of [3H]-Rauwolscine from human adrenergic alpha2B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting met...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi:  2.79E+3nMAssay Description:Displacement of [3H]-alpha-methylhistamine from human histamine H3 receptor expressed in HEK Flp-In cells after 90 mins by microbeta scintillation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
University of Texas At Austin

Curated by ChEMBL
LigandPNGBDBM50370625(CHEMBL4173095 | US10954217, Example 00241)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-Prazosin from human adrenergic alpha1B receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed