BDBM50370827 CHEMBL374569

SMILES OC(=O)c1ccc2cccnc2c1O

InChI Key InChIKey=JYIAZVFJRYLCBH-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50370827   

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
TBA

US Patent
LigandPNGBDBM50370827(CHEMBL374569 | US12377086, Compound 45)
Affinity DataKi:  280nMAssay Description:VIM-2 was diluted to 6 μM with 50 mM HEPES, pH 7.5, containing 150 mM NaCl. The diluted protein solution was used to make several 5 mL aliquots. L-Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetMetallo-beta lactamase [126-247,M154L](Klebsiella pneumoniae)
TBA

US Patent
LigandPNGBDBM50370827(CHEMBL374569 | US12377086, Compound 45)
Affinity DataKi:  350nMAssay Description:Nitrocefin (Cayman, CAS 41906-86-9) was used as the chromogenic substrate for all biochemical assays. The enzymatic activity of purified VIM-2 and ND...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetVIM-2 type metallo-beta-lactamase(Pseudomonas aeruginosa)
TBA

US Patent
LigandPNGBDBM50370827(CHEMBL374569 | US12377086, Compound 45)
Affinity DataIC50: 740nMAssay Description:VIM-2 was diluted to 6 μM with 50 mM HEPES, pH 7.5, containing 150 mM NaCl. The diluted protein solution was used to make several 5 mL aliquots. L-Ca...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetMetallo-beta lactamase [126-247,M154L](Klebsiella pneumoniae)
TBA

US Patent
LigandPNGBDBM50370827(CHEMBL374569 | US12377086, Compound 45)
Affinity DataIC50: 760nMAssay Description:Nitrocefin (Cayman, CAS 41906-86-9) was used as the chromogenic substrate for all biochemical assays. The enzymatic activity of purified VIM-2 and ND...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2025
Entry Details
US Patent

TargetEgl nine homolog 1(Human)
Procter and Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50370827(CHEMBL374569 | US12377086, Compound 45)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human EGLN1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetPolymerase acidic protein(Influenza A virus (strain A/Puerto Rico/8/1934 H1N...)
University of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50370827(CHEMBL374569 | US12377086, Compound 45)
Affinity DataEC50: >2.50E+5nMAssay Description:Plaque growth inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed