BDBM50375733 CHEMBL404259

SMILES Nc1ccc(cc1C(=O)NCC(=O)N[C@@H]1CCN(Cc2ccc(Cl)cc2)C1)C(F)(F)F

InChI Key InChIKey=BWUJEEUVCAHHTL-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50375733   

TargetC-C chemokine receptor type 2(Human)
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375733(CHEMBL404259)
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced chemotaxisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375733(CHEMBL404259)
Affinity DataIC50: 23.1nMAssay Description:Antagonist activity at human CCR2 in THP1 cells assessed as inhibition of MCP1-induced calcium fluxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375733(CHEMBL404259)
Affinity DataIC50: 26nMAssay Description:Displacement of [125I]MCP1 from human CCR2b in THP1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 2(Human)
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375733(CHEMBL404259)
Affinity DataIC50: 45nMAssay Description:Displacement of [125I]MCP1 from human CCR2b in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Deltagen Research Laboratories (Former Combichem)

Curated by ChEMBL
LigandPNGBDBM50375733(CHEMBL404259)
Affinity DataIC50: 1.00E+3nMAssay Description:Displacement of [125I]MCP1-alpha from human CCR1 in THP cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed