BDBM50378235 CHEMBL461557

SMILES CC[C@H](CO)Nc1nc(NCc2ccc(cc2)-c2ccccc2)c2ncn(C(C)C)c2n1

InChI Key InChIKey=BRJSFOFBYVFKCP-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50378235   

TargetCyclin-dependent kinase 12(Human)
UCB

Curated by ChEMBL
LigandPNGBDBM50378235(CHEMBL461557)
Affinity DataEC50:  17nMAssay Description:Inhibition of 6His-tagged wild type CDK12/cyclin K (unknown origin) infected in insect cells incubated for 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50378235(CHEMBL461557)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant CDK2/cyclin EMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
LigandPNGBDBM50378235(CHEMBL461557)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of recombinant CDK2/cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Pig)
Universite Paris-Descartes

Curated by ChEMBL
LigandPNGBDBM50378235(CHEMBL461557)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of pig brain GSK3alpha/betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2020
Entry Details Article
PubMed
LigandPNGBDBM50378235(CHEMBL461557)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at N-type Cav2.2 channel expressed in tsA201 cell assessed as calcium current by whole-cell patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed