BDBM50378948 CHEMBL2011431::US9394290, 36

SMILES C(c1cccnc1-c1cccs1)n1ccnc1

InChI Key InChIKey=SCXLPUWSFUALAY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50378948   

TargetCytochrome P450 11B1, mitochondrial(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50378948(CHEMBL2011431 | US9394290, 36)
Affinity DataIC50: 16nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone as substrate preincubated for 60 mins prior to subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 11B1, mitochondrial(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50378948(CHEMBL2011431 | US9394290, 36)
Affinity DataIC50: 16nMT: 2°CAssay Description:V79MZ cells expressing human CYP11B1 and human CYP11B2 genes, respectively, were grown on 24-well cell culture plates (8×10^5 cells per well) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetCytochrome P450 11B1, mitochondrial(Human)
Temple University

Curated by ChEMBL
LigandPNGBDBM50378948(CHEMBL2011431 | US9394290, 36)
Affinity DataIC50: 16nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79 MZ cells using [3H] 11 deoxycorticosterone as substrate by HPLC radioflow detectorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Universitaet Des Saarlandes Campus Saarbruecken

US Patent
LigandPNGBDBM50378948(CHEMBL2011431 | US9394290, 36)
Affinity DataIC50: 251nMT: 2°CAssay Description:V79MZ cells expressing human CYP11B1 and human CYP11B2 genes, respectively, were grown on 24-well cell culture plates (8×10^5 cells per well) w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details
US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Universitaet Des Saarlandes Campus Saarbruecken

US Patent
LigandPNGBDBM50378948(CHEMBL2011431 | US9394290, 36)
Affinity DataIC50: 251nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZ cells using [1,2-3H]11-deoxycorticosterone as substrate preincubated for 60 mins prior to subs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCytochrome P450 11B2, mitochondrial(Human)
Universitaet Des Saarlandes Campus Saarbruecken

US Patent
LigandPNGBDBM50378948(CHEMBL2011431 | US9394290, 36)
Affinity DataIC50: 251nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79 MZ cells using [3H] 11 deoxycorticosterone as substrate by HPLC radioflow detectorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed