BDBM50379197 CHEMBL2011266

SMILES Cc1cc2c(c(C(=O)NS(=O)(=O)C3CC3)n(Cc3cc(F)ccc3F)c2cc1F)-c1ccc[nH]c1=O

InChI Key InChIKey=GXKRHWPFLHJAKI-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50379197   

TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50379197(CHEMBL2011266)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 co-incubated with substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50379197(CHEMBL2011266)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 co-incubated with substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50379197(CHEMBL2011266)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 co-incubated with substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50379197(CHEMBL2011266)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C19 co-incubated with substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM50379197(CHEMBL2011266)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against HIV-1 Y188L reverse transcriptase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50379197(CHEMBL2011266)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 preincubated prior to substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50379197(CHEMBL2011266)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C19 preincubated prior to substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50379197(CHEMBL2011266)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 preincubated prior to substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50379197(CHEMBL2011266)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 preincubated prior to substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed