BDBM50379275 CHEMBL2011500

SMILES COc1ccc(cc1)C(=O)CC1(O)C(=O)Nc2c1c(Cl)ccc2Cl

InChI Key InChIKey=HLXSCTYHLQHQDJ-UHFFFAOYSA-N

Data  1 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50379275   

TargetEWS-Fli1 protein(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50379275(CHEMBL2011500)
Affinity DataKd:  9.48E+3nMAssay Description:Inhibition of interaction of EWS-Fli1 to GST-tagged RNA Helicase A (647-1075) by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFriend leukemia integration 1 transcription factor(Human)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50379275(CHEMBL2011500)
Affinity DataIC50:  350nMAssay Description:Inhibition of transcriptional activity of full-length EWS-FLI1 (unknown origin) expressed in COS7 cells by NR0B1-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetETS translocation variant 1(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50379275(CHEMBL2011500)
Affinity DataKd:  1.74E+4nMAssay Description:Binding affinity to ETV1 by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional regulator ERG(Human)
Broad Institute of Harvard and Mit

Curated by ChEMBL
LigandPNGBDBM50379275(CHEMBL2011500)
Affinity DataKd:  1.17E+4nMAssay Description:Binding affinity to ERG by surface plasmon resonanceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed