BDBM50379357 CHEMBL2011933

SMILES COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(=O)C3CCC3)c2[nH]1

InChI Key InChIKey=DECBFIYBUIMGPR-UHFFFAOYSA-N

Data  9 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50379357   

TargetSerine/threonine-protein kinase TBK1(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50379357(CHEMBL2011933)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant TBK1 using 5FAM-AhxKRRAL(ps)VASLPGL as substrate by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50379357(CHEMBL2011933)
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full-length TBK1 (unknown origin) using CK1tide as substrate by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50379357(CHEMBL2011933)
Affinity DataIC50: 6nMAssay Description:Inhibition of TBK1 in HEK293 cells after 4.5 hrs by ISRE-luciferase reporter gene assay in presence of poly I:CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase TBK1(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50379357(CHEMBL2011933)
Affinity DataEC50:  6nMAssay Description:Inhibition of TBK1-mediated NFkappaB activation expressed in ds-RNA activated HEK293 cells coexpressing TLR3 after 4.5 hrs by luciferase reporter gen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50379357(CHEMBL2011933)
Affinity DataIC50: 21nMAssay Description:Inhibition of Ikkepsilon using 5FAM-AKELDQGSLCTpSFVGTLQ-NH2 as substrate by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50379357(CHEMBL2011933)
Affinity DataIC50: 21nMAssay Description:Inhibition of IKK-epsilon (unknown origin) using 5FAM-AKELDQGSLCTpSFVGTLQ-NH2 as substrate by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50379357(CHEMBL2011933)
Affinity DataIC50: 38nMAssay Description:Inhibition of Aurora B kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50379357(CHEMBL2011933)
Affinity DataIC50: 38nMAssay Description:Inhibition of aurora B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50379357(CHEMBL2011933)
Affinity DataIC50: 4.91E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2014
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50379357(CHEMBL2011933)
Affinity DataIC50: 4.91E+3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed