BDBM50380029 CHEMBL2012627

SMILES OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)C(=O)Nc1nnc(Cc2ccc(F)cc2)s1

InChI Key InChIKey=RYFDRGQHYHFAMS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50380029   

TargetDiacylglycerol O-acyltransferase 1(Human)
Sanofi-Aventis R&D

Curated by ChEMBL
LigandPNGBDBM50380029(CHEMBL2012627)
Affinity DataIC50: 130nMAssay Description:Inhibition of DGAT-1 in human Chang cells assessed as lipid level after 6 hrs in presence of substrate [14C]glycerol by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Sanofi-Aventis R&D

Curated by ChEMBL
LigandPNGBDBM50380029(CHEMBL2012627)
Affinity DataIC50: 131nMAssay Description:Inhibition of human recombinant DGAT1 in Chang cells using [14C]-glycerol as substrate assessed as decrease in triglycerides synthesis after 6 hrs by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Sanofi-Aventis R&D

Curated by ChEMBL
LigandPNGBDBM50380029(CHEMBL2012627)
Affinity DataIC50: 600nMAssay Description:Inhibition of recombinant human DGAT-1 using 1,2,di(cis-9-octadecenoyl)-sn-glycerol as substrate by Microbeta counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetDiacylglycerol O-acyltransferase 1(Human)
Sanofi-Aventis R&D

Curated by ChEMBL
LigandPNGBDBM50380029(CHEMBL2012627)
Affinity DataIC50: 600nMAssay Description:Inhibition of human recombinant DGAT1 expressed in baculovirus infected Sf9 cells after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed