BDBM50380489 CHEMBL2018888

SMILES Nc1nc2ccccc2c2n(Cc3ccccc3)c(CCCc3nc4c(N)nc5ccccc5c4n3Cc3ccccc3)nc12

InChI Key InChIKey=MKGTVFYRRREUBJ-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50380489   

TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at TLR8 in human PBMC assessed as inhibition of CL075-induced IL-6 release after 12 hrs by bead array assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at TLR8 in human PBMC assessed as inhibition of CL075-TNF-alpha release after 12 hrs by bead array assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at TLR7 in human PBMC assessed as inhibition of gardiquimod-induced IL-8 release after 12 hrs by bead array assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at TLR7 in human PBMC assessed as inhibition of gardiquimod-induced IL-6 release after 12 hrs by bead array assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at TLR8 in human PBMC assessed as inhibition of CL075-induced IL-8 release after 12 hrs by bead array assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at TLR7 in human PBMC assessed as inhibition of gardiquimod-induced IL-1beta release after 12 hrs by bead array assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at TLR7 in human PBMC assessed as inhibition of gardiquimod-induced TNF-alpha release after 12 hrs by bead array assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at TLR7 in human PBMC assessed as inhibition of gardiquimod-induced CCL2 release after 12 hrs by bead array assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at TLR7 in human PBMC assessed as inhibition of gardiquimod-induced CXCL10 release after 12 hrs by bead array assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at TLR8 in human PBMC assessed as inhibition of CL075-induced CXCL10 release after 12 hrs by bead array assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at TLR8 in human PBMC assessed as inhibition of CL075-induced IL-1beta release after 12 hrs by bead array assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 50nMAssay Description:Antagonist activity at TLR8 in human PBMC assessed as inhibition of CL075-induced CCL2 release after 12 hrs by bead array assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 3.10E+3nMAssay Description:Antagonist activity at human TLR7 expressed in HEK-Blue cells assessed as inhibition of gardiquimod-induced NFkappaB activation by sAP reporter gene ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetToll-like receptor 8(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50380489(CHEMBL2018888)
Affinity DataIC50: 3.20E+3nMAssay Description:Antagonist activity at human TLR8 expressed in HEK-Blue cells assessed as inhibition of CL075-induced NFkappaB activation by sAP reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed