BDBM50381823 CHEMBL2023649

SMILES OC(=O)Cc1cnc(C(=O)c2ccc(NC(=O)c3ccc(Cl)c(Cl)c3)cc2)c2ccccc12

InChI Key InChIKey=CSVJLKCBGGRRIQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50381823   

TargetProstaglandin D2 receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381823(CHEMBL2023649)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human CRTH2 transfected in human KB8 cells assessed as inhibition of PGD2-induced increase in intracellular Ca2+ by fluo-4AM d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381823(CHEMBL2023649)
Affinity DataIC50: 19nMAssay Description:Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381823(CHEMBL2023649)
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381823(CHEMBL2023649)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at CRTH2 receptor in human Th2 cells assessed as inhibition of PGD2-induced chemotaxis after 1 hr by hemocytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381823(CHEMBL2023649)
Affinity DataIC50: 23nMAssay Description:Antagonist activity at CRTH2 in human TH2 cells assessed as inhibition of PGD2-induced chemotaxis after 1 hr by hemocytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381823(CHEMBL2023649)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to DP1 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381823(CHEMBL2023649)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DP1 prostanoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381823(CHEMBL2023649)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50381823(CHEMBL2023649)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of COX-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed