BDBM50384326 CHEMBL2030861

SMILES CCCCc1c(c(nn1c2ccccc2)CO)c3ccc(cc3C(=O)N4CCc5ccccc5C4)C(=O)NS(=O)(=O)CC[Si](C)(C)C

InChI Key InChIKey=KDMMHDWLRNJPDK-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50384326   

TargetBcl-2-like protein 1(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50384326(CHEMBL2030861)
Affinity DataIC50: 13nMAssay Description:Inhibition of GST-tagged Bcl-xL (unknown origin) measured after 1 hr incubation by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details Article
PubMed
TargetBcl-2-like protein 1(Human)
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50384326(CHEMBL2030861)
Affinity DataIC50: 13nMAssay Description:Inhibition of biotin-labelled Bcl-xL using [FAM]-IWIAQELRRIGDEFNAYY-NH2 as substrate after 60 mins by FRET analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetApoptosis regulator Bcl-2(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50384326(CHEMBL2030861)
Affinity DataIC50: 190nMAssay Description:Inhibition of GST-tagged Bcl2 using [FAM]-IWIAQELRRIGDEFNAYY-NH2 as substrate after 60 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed