BDBM50389684 CHEMBL2070051::US10307425, Example 119::US10632122, Example 119

SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC2CCNCC2)c2ncnc(N)c12

InChI Key InChIKey=ZOVKFJPIFCBGJO-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50389684   

TargetCAM kinase, CDPK family TgCDPK1(Toxoplasma gondii (strain ATCC 50861 / VEG))
University of Washington

US Patent
LigandPNGBDBM50389684(CHEMBL2070051 | US10307425, Example 119 | US106321...)
Affinity DataIC50: 3.40nMAssay Description:Inhibitors were evaluated in triplicate in eight-point dilutions (3-fold dilutions) during the enzymatic reactions. TgCDPK1 enzymatic inhibition was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
US Patent

TargetCalmodulin-domain protein kinase 1(Toxoplasma gondii)
University of Washington

US Patent
LigandPNGBDBM50389684(CHEMBL2070051 | US10307425, Example 119 | US106321...)
Affinity DataIC50: 3.40nMAssay Description:Inhibitors were evaluated in triplicate in eight-point dilutions (3-fold dilutions) during the enzymatic reactions. TgCDPK1 enzymatic inhibition was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389684(CHEMBL2070051 | US10307425, Example 119 | US106321...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR using poly glu-Tyr as substrate after 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetEphrin type-A receptor 3(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389684(CHEMBL2070051 | US10307425, Example 119 | US106321...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EPHA3 using myelin basic protein as substrate after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389684(CHEMBL2070051 | US10307425, Example 119 | US106321...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human p38alpha using myelin basic protein as substrate after 180 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389684(CHEMBL2070051 | US10307425, Example 119 | US106321...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human LCK using Ac-EIYGEFKKK-OH as substrate after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase CSK(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389684(CHEMBL2070051 | US10307425, Example 119 | US106321...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CSK using Ac-KKKKEEIYFFF-OH as substrate after 180 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389684(CHEMBL2070051 | US10307425, Example 119 | US106321...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human SRC using Ac-EIYGEFKKK-OH as substrate after 60 mins by phosphor imaging methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetTyrosine-protein kinase ABL1(Human)
University of Washington

Curated by ChEMBL
LigandPNGBDBM50389684(CHEMBL2070051 | US10307425, Example 119 | US106321...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ABL using EAIYAAPFAKKK-OH as substrate by phosphor imaging methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed