BDBM50393451 CHEMBL2159687

SMILES OCC[C@@H]1OCC[C@@]2([C@H]1COc1c(F)ccc(F)c21)S(=O)(=O)c1ccc(Cl)cc1

InChI Key InChIKey=OIAYKSYVOPWLJU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50393451   

TargetPresenilin-2(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393451(CHEMBL2159687)
Affinity DataIC50: 8nMAssay Description:Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPresenilin-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393451(CHEMBL2159687)
Affinity DataIC50: 18nMAssay Description:Inhibition of PS1 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-40 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPresenilin-1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50393451(CHEMBL2159687)
Affinity DataIC50: 20nMAssay Description:Inhibition of PS1 gamma-secretase assessed as reduction of amyloid beta-40 production by membrane based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed