BDBM50394779 CHEMBL2163394
SMILES Cc1cc(Nc2nc(Sc3ccc(NC(=O)CN4CC[C@H](C4)C(=O)NC4CCCC4)cc3)nn3cccc23)n[nH]1
InChI Key InChIKey=MXHHONGZVDTFNW-LJQANCHMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50394779
Affinity DataKd: 1.90nMAssay Description:Binding affinity to Aurora kinase B catalytic domain by competition binding assayMore data for this Ligand-Target Pair
Affinity DataKd: <10nMAssay Description:Binding affinity to Aurora kinase CMore data for this Ligand-Target Pair
Affinity DataKd: 9.30nMAssay Description:Inhibition of Aurora kinase A autophosphorylation in human HEK293 cells after 2 hrs by phosphor antibody readout assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of Aurora kinase B-mediated histone H3 Ser10 phosphorylation in human HCT116 cells after 2 hrs by sandwich ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of Aurora kinase A autophosphorylation in human HEK293 cells after 2 hrs by phosphor antibody readout assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Inhibition of Aurora kinase B in human HCT116 cells assessed as induction of 8N polyploidyMore data for this Ligand-Target Pair