BDBM50394893 CHEMBL2165502

SMILES CCc1nc2ccccc2n1-c1nc(N2CCOCC2)c2sc(CN3CCN(CC3(C)C)C3COC3)cc2n1

InChI Key InChIKey=SHTICQDOCLQFOS-UHFFFAOYSA-N

Data  3 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50394893   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Genentech

Curated by ChEMBL

LigandBDBM50394893(CHEMBL2165502)Copy SMILESCopy InChI

Affinity DataIC50: 2.30nMAssay Description:Binding affinity to PI3Kdelta after 30 mins by competitive fluorescence polarization assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Genentech

Curated by ChEMBL

LigandBDBM50394893(CHEMBL2165502)Copy SMILESCopy InChI

Affinity DataIC50: 102nMAssay Description:Inhibition of human PI3Kdelta-mediated AKT phosphorylation at S473 in Ri-1 cells after 30 mins by electrochemiluminescence assay in presence of human...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetCytochrome P450 3A4(Human)
Genentech

Curated by ChEMBL

LigandBDBM50394893(CHEMBL2165502)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes preincubated for 30 minsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL