BDBM50395226 CHEMBL2164676

SMILES O=C(NCC#N)[C@@H]1CCCC[C@H]1C(=O)N1CCN(CC1)c1ccccc1

InChI Key InChIKey=LNCZYHBVFQTPDF-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50395226   

TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395226(CHEMBL2164676)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant CatK assessed as suppression of enzyme-mediated Z-Phe-Arg-AMC cleavage incubated for 1 hrs by QFRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin K(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395226(CHEMBL2164676)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant cathepsin-k using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395226(CHEMBL2164676)
Affinity DataIC50: 455nMAssay Description:Inhibition of human recombinant CatB assessed as suppression of enzyme-mediated Z-Arg-Arg-AMC cleavage by QFRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin B(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395226(CHEMBL2164676)
Affinity DataIC50: 455nMAssay Description:Inhibition of human recombinant cathepsin-B using Z-Arg-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395226(CHEMBL2164676)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of human recombinant CatS assessed as suppression of enzyme-mediated Z-Val-Val-Arg-AMC cleavage by QFRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCathepsin S(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395226(CHEMBL2164676)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of human recombinant cathepsin-S using Z-Val-Val-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395226(CHEMBL2164676)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant cathepsin-L using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395226(CHEMBL2164676)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant CatL assessed as suppression of enzyme-mediated Z-Phe-Arg-AMC cleavage by QFRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed