BDBM50396612 CHEMBL2171926::US8765940, 4-(3,3-dimethyl-6-(4-pyridinyl)-2,3-dihydro-1H-indol-1-yl)-7-fluoro-3-methyl-2-(2-pyridinyl)quinoline

SMILES Cc1c(nc2cc(F)ccc2c1N1CC(C)(C)c2ccc(cc12)-c1ccncc1)-c1ccccn1

InChI Key InChIKey=QZMZREOJMMPRPH-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50396612   

LigandPNGBDBM50396612(CHEMBL2171926 | US8765940, 4-(3,3-dimethyl-6-(4-py...)
Affinity DataIC50: 81nMAssay Description:Inhibition of PI3Kbeta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396612(CHEMBL2171926 | US8765940, 4-(3,3-dimethyl-6-(4-py...)
Affinity DataIC50: 198nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396612(CHEMBL2171926 | US8765940, 4-(3,3-dimethyl-6-(4-py...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of PI3Kgamma by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396612(CHEMBL2171926 | US8765940, 4-(3,3-dimethyl-6-(4-py...)
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibition of PI3Kalpha by ATP bioluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50396612(CHEMBL2171926 | US8765940, 4-(3,3-dimethyl-6-(4-py...)
Affinity DataKi:  5.03E+3nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/18/2014
Entry Details
US Patent