BDBM50397892 CHEMBL2179527

SMILES Fc1coc(c1)C(=O)N1CC2CNCC2C1

InChI Key InChIKey=PLQXXAVXCSTSDP-UHFFFAOYSA-N

Data  4 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50397892   

TargetNeuronal acetylcholine receptor subunit alpha-4(Human)
Targacept

US Patent
LigandPNGBDBM50397892(CHEMBL2179527)
Affinity DataKi:  21nM ΔG°:  -10.3kcal/moleT: 21°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM50397892(CHEMBL2179527)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]nicotine from alpha4beta2 nAChR in human SH-EP1 cells after 2 hrs by liquid scintillation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397892(CHEMBL2179527)
Affinity DataKi:  36nM ΔG°:  -10.0kcal/moleT: 21°CAssay Description:The binding of [3H]MLA was measured using a modification of the methods of Davies et al., Neuropharmacol. 38: 679 (1999). [3H]MLA (Specific Activity=...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM50397892(CHEMBL2179527)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]epibatidine from human alpha7 nAChR expressed in CHO cells after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50397892(CHEMBL2179527)
Affinity DataEC50:  1.40E+3nMAssay Description:Agonist activity at alpha4beta2 nAChR in human SH-EP1 cells assessed as calcium flux by calcium4-based FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed