BDBM50398343 CHEMBL2178573::US9394307, 4-chloro-N-(5-methyl-2-{7H-pyrrolo[2,3-d]pyrimidine-4-carbonyl}pyridin-3-yl)-3-(trifluoromethyl)benzene-1-sulfonamide

SMILES Cc1cnc(C(=O)c2ncnc3[nH]ccc23)c(NS(=O)(=O)c2ccc(Cl)c(c2)C(F)(F)F)c1

InChI Key InChIKey=LUUMLYXKTPBTQR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50398343   

TargetC-C chemokine receptor type 2(Human)
National Heart and Lung Institute

Curated by ChEMBL
LigandPNGBDBM50398343(CHEMBL2178573 | US9394307, 4-chloro-N-(5-methyl-2-...)
Affinity DataIC50: 5nMAssay Description:Binding affinity to CCR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Chemocentryx

US Patent
LigandPNGBDBM50398343(CHEMBL2178573 | US9394307, 4-chloro-N-(5-methyl-2-...)
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:The test compounds were incubated with pooled human liver microsomes at 37° C. in the presence of NADPH and appropriate concentrations of substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
US Patent

TargetCytochrome P450 3A4(Human)
Chemocentryx

US Patent
LigandPNGBDBM50398343(CHEMBL2178573 | US9394307, 4-chloro-N-(5-methyl-2-...)
Affinity DataIC50: 2.00E+4nMT: 2°CAssay Description:The test compounds were incubated with pooled human liver microsomes at 37° C. in the presence of NADPH and appropriate concentrations of substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details
US Patent