BDBM50398667 CHEMBL2178135

SMILES COc1cc(c(cc1Nc2ncc(c(n2)NC3CC3)C(F)(F)F)F)C(=O)N4CCOCC4

InChI Key InChIKey=FKNAWDCGDQUZRV-UHFFFAOYSA-N

Data  1 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50398667   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Genentech

Curated by ChEMBL

LigandBDBM50398667(CHEMBL2178135)Copy SMILESCopy InChI

Affinity DataKi:  1nMAssay Description:Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Genentech

Curated by ChEMBL

LigandBDBM50398667(CHEMBL2178135)Copy SMILESCopy InChI

Affinity DataIC50: 4nMAssay Description:Inhibition of autophosphorylation of LRRK2 in human HEK293 cellsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidPDBSimilars

In Depth
Date in BDB:
5/17/2013
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL