BDBM50398670 CHEMBL2178132::US8802674, 297

SMILES CNc1nc(Nc2ccc(C(=O)N3CCOCC3)c(F)c2OC)ncc1C(F)(F)F

InChI Key InChIKey=VAHWMDOBYWCXJU-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50398670   

LigandPNGBDBM50398670(CHEMBL2178132 | US8802674, 297)
Affinity DataKi:  12nMAssay Description:Inhibition of LRRK2 using FAM-LRRKtide as substrate after 120 mins by microfluidic capillary electrophoresis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50398670(CHEMBL2178132 | US8802674, 297)
Affinity DataKi:  14.5nMAssay Description:This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/19/2015
Entry Details
US Patent

LigandPNGBDBM50398670(CHEMBL2178132 | US8802674, 297)
Affinity DataIC50: 35nMAssay Description:Inhibition of autophosphorylation of LRRK2 in human HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed