BDBM50399537 CHEMBL2180604

SMILES Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1

InChI Key InChIKey=DZFZXPPHBWCXPQ-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50399537   

TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 0.0930nMAssay Description:Inhibition of VEGFR2 (unknown origin) using biotinylated poly(Glu:Tyr) as substrate after 60 mins by AlphaScreen assay in presence of 1000 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of VEGFR2 (unknown origin) using biotinylated poly(Glu:Tyr) as substrate after 5 mins by AlphaScreen assay in presence of 10 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 0.950nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of VEGFR2 (unknown origin) using biotinylated poly(Glu:Tyr) as substrate after 5 mins by AlphaScreen assay in presence of 1000 uM of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of VEGFR3 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
University of Genoa

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of VEGFR1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of PDGFRalpha (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 10nMAssay Description:Inhibition of human FMSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 13nMAssay Description:Inhibition of PDGFRbeta (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 18nMAssay Description:Inhibition of human RETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 846nMAssay Description:The PDGFRα enzyme assays were conducted per the manufacturer's directions (Promega PDGFRα Kinase Enzyme System and ADP Glo Assay Cat #V8011). Bri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2025
Entry Details

TargetPlatelet-derived growth factor receptor beta(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50399537(CHEMBL2180604 | US20250129067, Compound TAK-593)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PDGFRbeta (unknown origin) incubated for 5 mins by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed