BDBM50400519 CHEMBL2204941

SMILES Fc1ccc(cc1)-c1c[nH]c(n1)[C@H]1Cc2c([nH]c3ccccc23)[C@H](N1)C1CCOCC1

InChI Key InChIKey=FRWHMBLUCGXEQQ-UHFFFAOYSA-N

Data  1 KI  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50400519   

TargetSomatostatin receptor type 3(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50400519(CHEMBL2204941)
Affinity DataIC50: 1.70nMAssay Description:Displacement of [125I]SS-28 from mouse SSTR3 transfected in CHO cells after 60 to 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSomatostatin receptor type 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50400519(CHEMBL2204941)
Affinity DataIC50: 2.80nMAssay Description:Binding affinity to human somatostatin receptor type 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2017
Entry Details Article
PubMed
TargetSomatostatin receptor type 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50400519(CHEMBL2204941)
Affinity DataIC50: 2.80nMAssay Description:Displacement of [125I]SS-28 from human SSTR3 transfected in CHO cells after 60 to 90 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSomatostatin receptor type 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50400519(CHEMBL2204941)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of human SSTR3 transfected in CHO cells assessed as inhibition of SRIF-induced reduction of cAMP accumulation after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSomatostatin receptor type 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50400519(CHEMBL2204941)
Affinity DataEC50:  5.70nMAssay Description:Antagonist activity at human somatostatin receptor type 3 assessed as inhibition of cAMP levelsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2017
Entry Details Article
PubMed
TargetSomatostatin receptor type 3(Mouse)
TBA

Curated by ChEMBL
LigandPNGBDBM50400519(CHEMBL2204941)
Affinity DataIC50: 26nMAssay Description:Inhibition of mouse SSTR3 transfected in CHO cells assessed as inhibition of SRIF-induced reduction of cAMP accumulation after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50400519(CHEMBL2204941)
Affinity DataIC50: 377nMAssay Description:Binding affinity to human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2017
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50400519(CHEMBL2204941)
Affinity DataKi:  377nMAssay Description:Displacement of radiolabeled MK-499 from human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed