BDBM50405894 CHEMBL5269770

SMILES COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1ccc2n(C)ncc2c1N1CC[C@@H](N)C1

InChI Key InChIKey=UKFXFNQXCIZAEM-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50405894   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405894(CHEMBL5269770)
Affinity DataKi:  3nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition constant incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405894(CHEMBL5269770)
Affinity DataIC50: 78nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405894(CHEMBL5269770)
Affinity DataKi:  211nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of SLP76 phosphorylation by measuring inhibition constant incubated for 1 hr by HTRF ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed