BDBM50405897 CHEMBL5277241

SMILES COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1ccc2sc(C)nc2c1N1CC[C@@H](N)C1

InChI Key InChIKey=TZPUNPWJLMOANL-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50405897   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405897(CHEMBL5277241)
Affinity DataKi: <1nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition constant incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405897(CHEMBL5277241)
Affinity DataIC50: 6.90nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405897(CHEMBL5277241)
Affinity DataKi:  23nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of SLP76 phosphorylation by measuring inhibition constant incubated for 1 hr by HTRF ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405897(CHEMBL5277241)
Affinity DataIC50: 53nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405897(CHEMBL5277241)
Affinity DataIC50: 198nMAssay Description:Inhibition of Lck (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405897(CHEMBL5277241)
Affinity DataIC50: 268nMAssay Description:Inhibition of PDGFRB (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
Target5'-AMP-activated protein kinase catalytic subunit alpha-1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50405897(CHEMBL5277241)
Affinity DataIC50: 409nMAssay Description:Inhibition of PRKAA1 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed