BDBM50406013 CHEMBL5267188

SMILES COc1cccc(F)c1-c1nccc(n1)C(=O)Nc1ccc(cc1N1C[C@@H](N)C[C@H]1CO)-c1c(C)nn(C)c1C#N

InChI Key InChIKey=YXFNNHJWPFANTQ-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50406013   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50406013(CHEMBL5267188)
Affinity DataKi: <1nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition constant incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50406013(CHEMBL5267188)
Affinity DataKi:  65nMAssay Description:Inhibition of HPK1 in human Jurkat cells assessed as inhibition of SLP76 phosphorylation by measuring inhibition constant incubated for 1 hr by HTRF ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50406013(CHEMBL5267188)
Affinity DataIC50: 127nMAssay Description:Inhibition of human HPK1 in human whole blood assessed as reduction in SLP76 phosphorylation incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine/threonine-protein kinase 4(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50406013(CHEMBL5267188)
Affinity DataIC50: 318nMAssay Description:Inhibition of STK4 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 2(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50406013(CHEMBL5267188)
Affinity DataIC50: 356nMAssay Description:Inhibition of MAP4K2 (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Incyte Research Institute

Curated by ChEMBL
LigandPNGBDBM50406013(CHEMBL5267188)
Affinity DataIC50: 3.93E+3nMAssay Description:Inhibition of TRKA (unknown origin) incubated for 90 mins in presence of ATP by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed