BDBM50406374 CHEMBL5266583

SMILES CC1(N)CCN(CC1)c1nc2ncc(Sc3cccnc3C(F)(F)F)nc2[nH]1

InChI Key InChIKey=YNZFEPJRFCYKBK-UHFFFAOYSA-N

Data  1 IC50  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50406374   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
IRBM

Curated by ChEMBL

LigandBDBM50406374(CHEMBL5266583)Copy SMILESCopy InChI

Affinity DataIC50: 74nMAssay Description:Allosteric inhibition of IRS1 peptide-activated human recombinant SHP2 (Met1 to Leu525) expressed in Escherichia coli assessed as inhibition of depho...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/18/2024
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
IRBM

Curated by ChEMBL

LigandBDBM50406374(CHEMBL5266583)Copy SMILESCopy InChI

Affinity DataEC50:  1.76E+3nMAssay Description:Allosteric inhibition of SHP2 in human KYSE-520 cells assessed as inhibition of ERK phosphorylation incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
4/18/2024
Entry Details
Copy BDB DOIPubMed
Copy reaction URL