BDBM50409189 CHEMBL5283402

SMILES CC1(C)C(N(Cc2ccc(cc2)C(=O)NO)c2ccccc12)c1cccnc1

InChI Key InChIKey=HGCZGYHCBRKJNB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50409189   

TargetHistone deacetylase 6(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 41nMAssay Description:Inhibition of C-terminal FLAG-tagged full-length recombinant human HDAC6 (1 to 1215 residues) expressed in Sf9 insect cells using a fluorogenic subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 42nMAssay Description:Inhibition of HDAC6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 42nMAssay Description:Inhibition of human recombinant HDAC6 using ZMAL (Z-(Ac)Lys-AMC) as fluorogenic substrate incubated for 120 mins by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 11(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 695nMAssay Description:Inhibition of full-length recombinant human HDAC11 (1 to 347 residues) extracted from Sf9 insect cells using a fluorogenic substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of human recombinant HDAC8 using FLUOR DE LYS fluorometric substrate pre-incubated for 15 mins and followed by substrate addition and meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of HDAC8 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of C-terminal His-tagged full-length recombinant human HDAC8 (1 to 377 residues) expressed in Sf9 insect cells using a fluorogenic substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 5.33E+3nMAssay Description:Inhibition of human recombinant HDAC1 using ZMAL (Z-(Ac)Lys-AMC) as fluorogenic substrate incubated for 120 mins by microplate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 5.33E+3nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 5.42E+3nMAssay Description:Inhibition of C-terminal 6xHis-tagged full-length recombinant human HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using a fluorogenic subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 5.87E+3nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC3 (1 to 428 residues) expressed in baculovirus infected Sf9 insect cells co-expressing NCOR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50409189(CHEMBL5283402)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-terminal His-tagged recombinant human HDAC5 catalytic domain (656 to 1122 residues) expressed in baculovirus infected Sf9 insect cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed