BDBM50413958 CHEMBL240177

SMILES COc1ncccc1NC(NC(NC(=O)c1ccc(Cl)cc1)C(C)(Cl)Cl)=NC#N

InChI Key InChIKey=PCYQNSRPJFTODK-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50413958   

TargetP2X purinoceptor 7(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50413958(CHEMBL240177)
Affinity DataIC50: 50.1nMAssay Description:Antagonist activity at rat cloned P2X7 receptor expressed in HEK293 cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetP2X purinoceptor 7(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50413958(CHEMBL240177)
Affinity DataIC50: 63.1nMAssay Description:Antagonist activity at human cloned P2X7 receptor expressed in HEK293 cells assessed as inhibition of calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetATP-sensitive inward rectifier potassium channel 11(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50413958(CHEMBL240177)
Affinity DataEC50:  9.77E+3nMAssay Description:Channel opening activity at human bladder Kir6.2 channel containing SUR2B expressed in L cells by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed