BDBM50415046 CHEMBL583658

SMILES Cc1cccc(n1)C(=O)N[C@H]1C[C@H](C1)n1cnc(NC(=O)Cc2cccc3ccccc23)c1

InChI Key InChIKey=WESLFWSZUGLONY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50415046   

TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50415046(CHEMBL583658)
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP by radiometric scintillation counter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50415046(CHEMBL583658)
Affinity DataIC50: 6nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Southwest Jiaotong University

Curated by ChEMBL
LigandPNGBDBM50415046(CHEMBL583658)
Affinity DataIC50: 108nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50415046(CHEMBL583658)
Affinity DataIC50: 230nMAssay Description:Inhibition of human CDK5/p25 expressed in CHO cells after 2 hrs by whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed