BDBM50420729 CHEMBL2087490

SMILES CCS(=O)(=O)N1CCN(Cc2cn3cc(nc(N4CCOCC4)c3n2)-c2cnc(N)nc2)CC1

InChI Key InChIKey=YSZKJGOGZGYCHQ-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50420729   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL

LigandBDBM50420729(CHEMBL2087490)Copy SMILESCopy InChI

Affinity DataIC50: 13.3nMAssay Description:Inhibition of human PI3Kalpha (p110alpha/p85alpha) by ADP accumulation based HTRF assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/22/2013
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Spanish National Cancer Research Centre (Cnio)

Curated by ChEMBL

LigandBDBM50420729(CHEMBL2087490)Copy SMILESCopy InChI

Affinity DataIC50: 98.5nMAssay Description:Inhibition of PI3Kalpha in human U2OS cells assessed as inhibition of AKT Ser 473 phosphorylation by Western blotMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
5/22/2013
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL