BDBM50420836 CHEMBL2086690

SMILES CC(C)c1nc(no1)N1CCN([C@H](C)C1)c1ncc(OCc2ccncc2C#N)cn1

InChI Key InChIKey=UNGZTVLHLKAKQE-UHFFFAOYSA-N

Data  8 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50420836   

TargetGlucose-dependent insulinotropic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from human G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human GPR119 overexpressed in HEK293S cells assessed as change in cAMP level after 45 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human GPR119 receptor over expressed in HEK293S cells assessed as increase in cAMP level after 45 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataEC50:  56nMAssay Description:Agonist activity at mouse GPR119 receptor assessed as increase in cAMP level after 45 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataEC50:  56nMAssay Description:Agonist activity at mouse GPR119 overexpressed in HEK293S cells assessed as change in cAMP level after 45 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetGlucose-dependent insulinotropic receptor(Mouse)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: 568nMAssay Description:Displacement of [3H]-N-(2-fluoro-4-methylsulfonyl-phenyl)-6-[4-(3-isopropyl-1,2,4-oxadiazol-5-yl)-1-piperidyl]-5-nitro-pyrimidin-4-amine from mouse G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C19 by high-throughput fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9 by high-throughput fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 by high-throughput fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 by high-throughput fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50420836(CHEMBL2086690)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP1A2 by high-throughput fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed