BDBM50424405 CHEMBL2315071

SMILES Nc1ncc(-c2cccnc2)c2scc(-c3cccc(NC(=O)Cc4cccs4)c3)c12

InChI Key InChIKey=ITQPAYAQGJMSTK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50424405   

TargetSerine/threonine-protein kinase B-raf(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50424405(CHEMBL2315071)
Affinity DataIC50: 45nMAssay Description:Inhibition of B-Raf (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50424405(CHEMBL2315071)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of B-Raf (unknown origin) expressed in mouse 3T3 cells co-expressing FLAG-tagged MEK1 assessed as inhibition of MEK1 phosphorylation after...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed