BDBM50425434 CHEMBL2312640

SMILES Clc1cccc(N2CCN(CCCCNS(=O)(=O)c3cncc4ccccc34)CC2)c1Cl

InChI Key InChIKey=HNYKNGYYMXLUFG-UHFFFAOYSA-N

Data  6 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50425434   

TargetD(2) dopamine receptor(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425434(CHEMBL2312640)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]-raclopride from human dopamine D2L receptor expressed in HEK293 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425434(CHEMBL2312640)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK293 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425434(CHEMBL2312640)
Affinity DataKi:  59nMAssay Description:Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HEK293 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425434(CHEMBL2312640)
Affinity DataKi:  90nMAssay Description:Displacement of [3H]-ketanserin from human 5HT2A receptor expressed in HEK293 after 1.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425434(CHEMBL2312640)
Affinity DataKi:  220nMAssay Description:Displacement of [3H]-LSD from human 5HT6 receptor expressed in HEK293 after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425434(CHEMBL2312640)
Affinity DataKi:  783nMAssay Description:Displacement of [3H]-citalopram from SERT in rat cerebral cortex after 1 hr by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425434(CHEMBL2312640)
Affinity DataIC50: 820nMAssay Description:Antagonist activity at human 5HT7 receptor expressed in HEK293 assessed as inhibition of 5HT-induced cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Jagiellonian University Medical College

Curated by ChEMBL
LigandPNGBDBM50425434(CHEMBL2312640)
Affinity DataEC50:  1.50E+4nMAssay Description:Agonist activity at human 5HT1A receptor expressed in CHO cells assessed as cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed