BDBM50425649 CHEMBL2315239
SMILES NC(=N)c1ccc(CNC(=O)[C@@H]2Cc3ccc(NC(=O)CN4CCN(CC4)CC(=O)Nc4ccc(C[C@@H](NS(=O)(=O)Cc5ccccc5)C(=O)N2)cc4)cc3)cc1
InChI Key InChIKey=KODRHCNJBWRWGP-MPQUPPDSSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 50425649
Affinity DataKi: 0.680nMAssay Description:Inhibition of human plasmin protease domain using Tos-Gly-Pro-Lys-pNA as substrate by micro plate reader analysisMore data for this Ligand-Target Pair
Affinity DataKi: 44nMAssay Description:Inhibition of human trypsinMore data for this Ligand-Target Pair
Affinity DataKi: 63nMAssay Description:Inhibition of pig trypsin using CH3SO2-D-Cha-Gly-Arg-pNA as substrate after 5 to 10 mins by micro plate reader analysisMore data for this Ligand-Target Pair
Affinity DataKi: 320nMAssay Description:Inhibition of human plasma kallikrein using H-D-Pro-Phe-Arg-pNA as substrate after 5 to 10 mins by micro plate reader analysisMore data for this Ligand-Target Pair
Affinity DataKi: 4.70E+3nMAssay Description:Inhibition of human FXIaMore data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Philipps University Marburg
Curated by ChEMBL
Philipps University Marburg
Curated by ChEMBL
Affinity DataKi: 8.90E+3nMAssay Description:Inhibition of human uPAMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human factor Xa using CH3OCO-D-Cha-Gly-Arg-pNA as substrate after 5 to 10 mins by micro plate reader analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.39E+4nMAssay Description:Inhibition of human thrombin using CH3SO2-D-Cha-Gly-Arg-pNA as substrate after 5 to 10 mins by micro plate reader analysisMore data for this Ligand-Target Pair
TargetVitamin K-dependent protein C(Homo sapiens (Human))
Philipps University Marburg
Curated by ChEMBL
Philipps University Marburg
Curated by ChEMBL
Affinity DataKi: >2.50E+4nMAssay Description:Inhibition of human activated protein C using H-D-Lys(Cbz)-Pro-Arg-pNA as substrate after 5 to 10 mins by micro plate reader analysisMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Inhibition of human FVIIaMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human C1rMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of urinary kallikrein (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human C1sMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human FIXaMore data for this Ligand-Target Pair
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Philipps University Marburg
Curated by ChEMBL
Philipps University Marburg
Curated by ChEMBL
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human tPAMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human FXIIaMore data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human recombinant CYP2D6 expressed in Trichoplusia ni BTI-TN-5B1-4 cells preincubated for 15 mins measured after 45 mins by spectrofluo...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant CYP2C9 expressed in Trichoplusia ni BTI-TN-5B1-4 cells preincubated for 15 mins measured after 45 mins by spectrofluo...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant CYP1A2 expressed in Trichoplusia ni BTI-TN-5B1-4 cells preincubated for 15 mins measured after 30 mins by spectrofluo...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant CYP2C19 expressed in Trichoplusia ni BTI-TN-5B1-4 cells preincubated for 15 mins measured after 45 mins by spectroflu...More data for this Ligand-Target Pair
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of human recombinant CYP3A4 expressed in Trichoplusia ni BTI-TN-5B1-4 cells preincubated for 15 mins measured after 30 mins by spectrofluo...More data for this Ligand-Target Pair