BDBM50426448 CHEMBL2322666

SMILES CC[C@H](C)[C@H](N)C(=O)N1CCN(CC1)c1nc(nc(n1)-n1c(nc2ccccc12)C(F)F)N1CCOCC1

InChI Key InChIKey=QGQJNXQVPVENJB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50426448   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50426448(CHEMBL2322666)
Affinity DataIC50: 67nMAssay Description:Inhibition of PI3K-beta (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 10 uM ATP as substrate m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50426448(CHEMBL2322666)
Affinity DataIC50: 140nMAssay Description:Inhibition of wild type PI3K-beta (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 100 uM ATP as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50426448(CHEMBL2322666)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PI3K-delta (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 10 uM ATP as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50426448(CHEMBL2322666)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of PI3K-alpha (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 10 uM ATP as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50426448(CHEMBL2322666)
Affinity DataIC50: 9.20E+3nMAssay Description:Inhibition of wild type PI3K-alpha (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 100 uM ATP as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Monash University (Parkville Campus)

Curated by ChEMBL
LigandPNGBDBM50426448(CHEMBL2322666)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3K-gamma (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 10 uM ATP as substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed