BDBM50427225 CHEMBL2325101

SMILES Clc1ccc(cc1Cl)C1=NN(C(C1)c1ccc2ccccc2c1)c1ccccc1

InChI Key InChIKey=PWQAYVPGWSRNKH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50427225   

TargetEpidermal growth factor receptor(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50427225(CHEMBL2325101)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant EGFR cytoplasmic domain (645 to 1186) (unknown origin) autophosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50427225(CHEMBL2325101)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of human recombinant HER-2 cytoplasmic domain (676 to 1245) autophosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50427225(CHEMBL2325101)
Affinity DataIC50: 1.83E+3nMAssay Description:Inhibition of VEGFR-2 (unknown origin) using gastrin as substrate after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetFocal adhesion kinase 1(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50427225(CHEMBL2325101)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of human-recombinant full-length FAK after 4 hrs by kinase-Glo-luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-3(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50427225(CHEMBL2325101)
Affinity DataIC50: 3.59E+4nMAssay Description:Inhibition of human recombinant HER-3 cytoplasmic domain (665 to 1339) autophosphorylation after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed