BDBM50427454 CHEMBL2322239::US10308662, Compound 6::US9505780, 6

SMILES O=c1cc(oc2c(csc12)-c1ccccc1)N1CCOCC1

InChI Key InChIKey=ROWRIIZUTZDVNX-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50427454   

LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 297nMAssay Description:Inhibition of PI3K p110alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 297nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 297nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 378nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 378nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 378nMAssay Description:Inhibition of PI3K p110beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
The University of Arizona

Curated by ChEMBL
LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 610nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 784nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 784nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 784nMAssay Description:Inhibition of PI3K p110delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of PI3K p110gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 1.57E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [75-147](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 2.17E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [44-167](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4 [368-440](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 3.45E+3nMAssay Description:Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2017
Entry Details
US Patent

TargetBromodomain-containing protein 4 [349-460](Human)
Signal Rx Pharmaceuticals

US Patent
LigandPNGBDBM50427454(CHEMBL2322239 | US9505780, 6 | US10308662, Compoun...)
Affinity DataIC50: 3.45E+3nMAssay Description:Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/15/2020
Entry Details
US Patent