BDBM50429412 CHEMBL2338582

SMILES O=C(N[C@H]1CCC[C@]2(CN=C(c3cccc(Cl)c3)O2)C1)c1ccccn1

InChI Key InChIKey=WULJJNIUCIHCRO-UHFFFAOYSA-N

Data  2 KI  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50429412   

TargetMetabotropic glutamate receptor 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429412BDBM50429412(CHEMBL2338582)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-ABP688 from human mGluR5 expressed in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429412BDBM50429412(CHEMBL2338582)
Affinity DataIC50: 115nMAssay Description:Antagonist activity at human mGluR5 expressed in HEK293 cells assessed as inhibition of Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429412BDBM50429412(CHEMBL2338582)
Affinity DataKi:  178nMAssay Description:Displacement of [3H]-ABP688 from human mGluR5 expressed in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429412BDBM50429412(CHEMBL2338582)
Affinity DataIC50: 647nMAssay Description:Antagonist activity at human mGluR5 expressed in HEK293 cells assessed as inhibition of Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Lundbeck Research Usa

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429412BDBM50429412(CHEMBL2338582)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at rat mGluR1 expressed in HEK293 cells assessed as inhibition of Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 1(Rat)
Lundbeck Research Usa

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50429412BDBM50429412(CHEMBL2338582)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at rat mGluR1 expressed in HEK293 cells assessed as Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed