BDBM50431138 CHEMBL2332097
SMILES COc1cccc(CN(C)C(=O)Nc2ccc(cc2)-c2cn[nH]c2)c1
InChI Key InChIKey=MTJPSOHLRSAFBG-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50431138
Affinity DataIC50: 1nMAssay Description:Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF modeMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of ROCK2 (unknown origin) using STK2 substrate after 4 hrs by HTRF modeMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of ROCK1 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of ROCK2 (unknown origin) after 4 hrs by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of JNK3 alpha1 (unknown origin) using biotinylated Flag-ATF2 as substrate after 15 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP3A4 (unknown origin)-mediated midazolam hydroxylation to 1'-HydroxymidazolamMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2D6 (unknown origin)-mediated bufuralol hydroxylation to 4'-HydroxybufuralolMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)-mediated phenaceten demethylation to acetaminophenMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase MRCK alpha(Human)
The Scripps Research Institute
Curated by ChEMBL
The Scripps Research Institute
Curated by ChEMBL
Affinity DataIC50: 1.85E+3nMAssay Description:Inhibition of MRCKalpha (unknown origin) using LCD-AKRRRRLSSLRA-NH2 as substrate after 75 mins by luminescence assay in presence of [33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Inhibition of CYP2C9 (unknown origin)-mediated tolbutamide hydroxylation to hydroxy tolbutamideMore data for this Ligand-Target Pair