BDBM50431521 CHEMBL2348864

SMILES O=C1CN(CCC2CCOCC2)c2nc(cnc2N1)-c1ccc(cc1)-c1nnc[nH]1

InChI Key InChIKey=MLNSAGOBCFMEKI-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50431521   

LigandPNGBDBM50431521(CHEMBL2348864)
Affinity DataIC50:  530nMAssay Description:Inhibition of PI3K-alpha (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50431521(CHEMBL2348864)
Affinity DataIC50:  8nMAssay Description:Inhibition of mTOR (unknown origin) by HTR-FRET substrate phosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50431521(CHEMBL2348864)
Affinity DataIC50:  526nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50431521(CHEMBL2348864)
Affinity DataIC50:  46nMAssay Description:Inhibition of mTORC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50431521(CHEMBL2348864)
Affinity DataIC50:  34nMAssay Description:Inhibition of mTOR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50431521(CHEMBL2348864)
Affinity DataIC50:  526nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTarget of rapamycin complex subunit LST8(Homo sapiens)
University Of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50431521(CHEMBL2348864)
Affinity DataIC50:  8nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Celgene

Curated by ChEMBL
LigandPNGBDBM50431521(CHEMBL2348864)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant mTOR (unknown origin) using GST-p70S6 as substrate after 60 mins by TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed