BDBM50432562 CHEMBL2347005::US9115116, 12a

SMILES C[C@@H]1C[C@H](OC(=O)NCCCCCCC(=O)NO)[C@@H]2[C@@H](CC[C@@H]3C[C@H](CC(=O)O3)O[Si](C)(C)C(C)(C)C)[C@@H](C)C=CC2=C1

InChI Key InChIKey=GEYMFTUKZLBUPW-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50432562   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50432562(CHEMBL2347005 | US9115116, 12a)
Affinity DataIC50: 54nMAssay Description:Inhibition of recombinant HMG-CoA reductase (unknown origin) after 10 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50432562(CHEMBL2347005 | US9115116, 12a)
Affinity DataIC50: 54.1nMpH: 7.4Assay Description:The HMGR activity was performed using HMG-CoA reductase assay kit from Sigma-Aldrich with the human recombinant protein or 100 μg total cell lys...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50432562(CHEMBL2347005 | US9115116, 12a)
Affinity DataIC50: 122nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50432562(CHEMBL2347005 | US9115116, 12a)
Affinity DataIC50: 122nMT: 2°CAssay Description:The HDAC activity was performed using the HDAC fluorescent activity assay kit (BIOMOL, Plymouth Meeting, Pa., USA) according to the manufacturer'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
National Taiwan University

US Patent
LigandPNGBDBM50432562(CHEMBL2347005 | US9115116, 12a)
Affinity DataIC50: 140nMT: 2°CAssay Description:The HDAC activity was performed using the HDAC fluorescent activity assay kit (BIOMOL, Plymouth Meeting, Pa., USA) according to the manufacturer'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
National Taiwan University

US Patent
LigandPNGBDBM50432562(CHEMBL2347005 | US9115116, 12a)
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant HDAC6 (unknown origin) after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
National Taiwan University

US Patent
LigandPNGBDBM50432562(CHEMBL2347005 | US9115116, 12a)
Affinity DataIC50: 658nMT: 2°CAssay Description:The HDAC activity was performed using the HDAC fluorescent activity assay kit (BIOMOL, Plymouth Meeting, Pa., USA) according to the manufacturer'...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2016
Entry Details
US Patent

TargetHistone deacetylase 2(Human)
National Taiwan University

US Patent
LigandPNGBDBM50432562(CHEMBL2347005 | US9115116, 12a)
Affinity DataIC50: 658nMAssay Description:Inhibition of recombinant HDAC2 (unknown origin) after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50432562(CHEMBL2347005 | US9115116, 12a)
Affinity DataIC50: 1.32E+4nMAssay Description:Inhibition of HMG-CoA reductase in human A549 cells after 5 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed