BDBM50434347 CHEMBL2386753::US9446044, 48

SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc5OCOc5c4)c3c2s1

InChI Key InChIKey=OTKQTETZDVGXBV-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50434347   

LigandPNGBDBM50434347(CHEMBL2386753 | US9446044, 48)
Affinity DataIC50: 1.65nMpH: 7.5 T: 2°CAssay Description:The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
US Patent

LigandPNGBDBM50434347(CHEMBL2386753 | US9446044, 48)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant DYRK1A (unknown origin) after 120 mins in presence of [33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50434347(CHEMBL2386753 | US9446044, 48)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of recombinant DYRK1B (unknown origin) after 120 mins in presence of [33P]-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
LigandPNGBDBM50434347(CHEMBL2386753 | US9446044, 48)
Affinity DataIC50: 4.20nMpH: 7.5 T: 2°CAssay Description:The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2017
Entry Details
US Patent

LigandPNGBDBM50434347(CHEMBL2386753 | US9446044, 48)
Affinity DataIC50: 47nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetGlycogen synthase kinase-3(Human)
University of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM50434347(CHEMBL2386753 | US9446044, 48)
Affinity DataIC50: 660nMAssay Description:Inhibition of GSK3alpha/beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
University of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM50434347(CHEMBL2386753 | US9446044, 48)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
University of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM50434347(CHEMBL2386753 | US9446044, 48)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed