BDBM50435080 CHEMBL2391518

SMILES OC(=O)Cn1cc(\C=C(/C#N)C(=O)N2CCCc3ccccc23)c2ccccc12

InChI Key InChIKey=GPOINCDNNRDNCO-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50435080   

TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50435080(CHEMBL2391518)
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 receptor in presence of human serum albuminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50435080(CHEMBL2391518)
Affinity DataIC50: 14nMAssay Description:Displacement of [3H]PGD2 from human CRTh2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50435080(CHEMBL2391518)
Affinity DataIC50: 54nMAssay Description:Antagonist activity at PGD2-induced human CRTh2 receptor activation expressed in HEK293 cells assessed as intracellular Ca2+ liberation by FLIPR assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor 2(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50435080(CHEMBL2391518)
Affinity DataIC50: 160nMAssay Description:Antagonist activity against CRTh2 receptor in human eosinophils assessed as cell shape changeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetProstaglandin D2 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50435080(CHEMBL2391518)
Affinity DataIC50: 8.20E+3nMAssay Description:Inhibition of PGD2 binding to human DP1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50435080(CHEMBL2391518)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50435080(CHEMBL2391518)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetThromboxane A2 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50435080(CHEMBL2391518)
Affinity DataIC50: 2.50E+4nMAssay Description:Antagonist activity at human TP2 receptor assessed as inhibition of U46619-induced Ca2+ mobilization by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed